Cefaclorum [INN-Latin]

Cefaclorum [INN-Latin] Brand names, Cefaclorum [INN-Latin] Analogs

Cefaclorum [INN-Latin] Brand Names Mixture

No information avaliable

Cefaclorum [INN-Latin] Chemical_Formula

C₁₅H₁₄ClN₃O₄S

Cefaclorum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic/cefaclor.htm

Cefaclorum [INN-Latin] fda sheet

Cefaclorum_[INN-Latin] FDA

Cefaclorum [INN-Latin] msds (material safety sheet)

Cefaclorum_[INN-Latin] MSDS

Cefaclorum [INN-Latin] Synthesis Reference

R. R. Chauvette, U.S. Pat. 3,925,372 (1975)

Cefaclorum [INN-Latin] Molecular Weight

367.808 g/mol

Cefaclorum [INN-Latin] Melting Point

327 ^oC

Cefaclorum [INN-Latin] H₂O Solubility

8.6 mg/mL

Cefaclorum [INN-Latin] State

Solid

Cefaclorum [INN-Latin] LogP

0.517

Cefaclorum [INN-Latin] Dosage Forms

Capsule; Powder; Powder for solution; Powder for suspension; Suspension

Cefaclorum [INN-Latin] Indication

For the treatment of certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections.

Cefaclorum [INN-Latin] Pharmacology

Cefaclor is a second generation cephalosporin antibiotic with a spectrum resembling first-generation cephalosporins. In vitro tests demonstrate that the bactericidal action of the cephalosporins results from inhibition of cell-wall synthesis. Cefaclor has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections: Gram positive aerobes - Staphylococci (including coagulase-positive, coagulase-negative, and penicillinase-producing strains), Streptococcus pneumoniae, and Streptococcus pyogenes (group A ß-hemolytic streptococci). Gram-negative aerobes - Escherichia coli, Haemophilus influenzae (including ß-lactamase-producing ampicillin-resistant strains), Klebsiella sp, and Proteus mirabilis.

Cefaclorum [INN-Latin] Absorption

Well absorbed after oral administration, independent of food intake.

Cefaclorum [INN-Latin] side effects and Toxicity

Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.

Cefaclorum [INN-Latin] Patient Information

Patients should be counseled that antibacterial drugs including Ceclor should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Ceclor is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Ceclor or other antibacterial drugs in the future.

Cefaclorum [INN-Latin] Organisms Affected

Enteric bacteria and other eubacteria